Spotted fever group rickettsioses in Israel, 2010–2019

Regev Cohen; Talya Finn; Frida Babushkin; Yael Paran; Ronen Ben Ami; Alaa Atamna; Sharon Reisfeld; Gabriel Weber; Neta Petersiel; Hiba Zayyad; Eyal Leshem; Miriam Weinberger; Yasmin Maor; Nicola Makhoul; Lior Nesher; Galia Zaide; Dar Klein; Adi Beth-Din; Yafit Atiya-Nasagi

doi:10.3201/eid2708.203661

Spotted fever group rickettsioses in Israel, 2010–2019

Regev Cohen, Talya Finn, Frida Babushkin, Yael Paran, Ronen Ben Ami, Alaa Atamna, Sharon Reisfeld, Gabriel Weber, Neta Petersiel, Hiba Zayyad, Eyal Leshem, Miriam Weinberger, Yasmin Maor, Nicola Makhoul, Lior Nesher, Galia Zaide, Dar Klein, Adi Beth-Din, Yafit Atiya-Nasagi

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Abstract

In a multicenter, nationwide, retrospective study of patients hospitalized with spotted fever group rickettsiosis in Israel during 2010–2019, we identified 42 cases, of which 36 were autochthonous. The most prevalent species was the Rickettsia conorii Israeli tick typhus strain (n = 33, 79%); infection with this species necessitated intensive care for 52% of patients and was associated with a 30% fatality rate. A history of tick bite was rare, found for only 5% of patients; eschar was found in 12%; and leukocytosis was more common than leukopenia. Most (72%) patients resided along the Mediterranean shoreline. For 3 patients, a new Rickettsia variant was identified and had been acquired in eastern, mountainous parts of Israel. One patient had prolonged fever before admission and clinical signs resembling tickborne lymphadenopathy. Our findings suggest that a broad range of Rickettsia species cause spotted fever group rickettsiosis in Israel.

Original language	English
Pages (from-to)	2117-2126
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	27
Issue number	8
DOIs	https://doi.org/10.3201/eid2708.203661
State	Published - 1 Aug 2021

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Cohen, R., Finn, T., Babushkin, F., Paran, Y., Ami, R. B., Atamna, A., Reisfeld, S., Weber, G., Petersiel, N., Zayyad, H., Leshem, E., Weinberger, M., Maor, Y., Makhoul, N., Nesher, L., Zaide, G., Klein, D., Beth-Din, A., & Atiya-Nasagi, Y. (2021). Spotted fever group rickettsioses in Israel, 2010–2019. Emerging Infectious Diseases, 27(8), 2117-2126. https://doi.org/10.3201/eid2708.203661

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title = "Spotted fever group rickettsioses in Israel, 2010–2019",

abstract = "In a multicenter, nationwide, retrospective study of patients hospitalized with spotted fever group rickettsiosis in Israel during 2010–2019, we identified 42 cases, of which 36 were autochthonous. The most prevalent species was the Rickettsia conorii Israeli tick typhus strain (n = 33, 79%); infection with this species necessitated intensive care for 52% of patients and was associated with a 30% fatality rate. A history of tick bite was rare, found for only 5% of patients; eschar was found in 12%; and leukocytosis was more common than leukopenia. Most (72%) patients resided along the Mediterranean shoreline. For 3 patients, a new Rickettsia variant was identified and had been acquired in eastern, mountainous parts of Israel. One patient had prolonged fever before admission and clinical signs resembling tickborne lymphadenopathy. Our findings suggest that a broad range of Rickettsia species cause spotted fever group rickettsiosis in Israel.",

author = "Regev Cohen and Talya Finn and Frida Babushkin and Yael Paran and Ami, {Ronen Ben} and Alaa Atamna and Sharon Reisfeld and Gabriel Weber and Neta Petersiel and Hiba Zayyad and Eyal Leshem and Miriam Weinberger and Yasmin Maor and Nicola Makhoul and Lior Nesher and Galia Zaide and Dar Klein and Adi Beth-Din and Yafit Atiya-Nasagi",

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month = aug,

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doi = "10.3201/eid2708.203661",

language = "English",

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Cohen, R, Finn, T, Babushkin, F, Paran, Y, Ami, RB, Atamna, A, Reisfeld, S, Weber, G, Petersiel, N, Zayyad, H, Leshem, E, Weinberger, M, Maor, Y, Makhoul, N, Nesher, L, Zaide, G, Klein, D, Beth-Din, A & Atiya-Nasagi, Y 2021, 'Spotted fever group rickettsioses in Israel, 2010–2019', Emerging Infectious Diseases, vol. 27, no. 8, pp. 2117-2126. https://doi.org/10.3201/eid2708.203661

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AU - Cohen, Regev

AU - Finn, Talya

AU - Babushkin, Frida

AU - Paran, Yael

AU - Ami, Ronen Ben

AU - Atamna, Alaa

AU - Reisfeld, Sharon

AU - Weber, Gabriel

AU - Petersiel, Neta

AU - Zayyad, Hiba

AU - Leshem, Eyal

AU - Weinberger, Miriam

AU - Maor, Yasmin

AU - Makhoul, Nicola

AU - Nesher, Lior

AU - Zaide, Galia

AU - Klein, Dar

AU - Beth-Din, Adi

AU - Atiya-Nasagi, Yafit

PY - 2021/8/1

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N2 - In a multicenter, nationwide, retrospective study of patients hospitalized with spotted fever group rickettsiosis in Israel during 2010–2019, we identified 42 cases, of which 36 were autochthonous. The most prevalent species was the Rickettsia conorii Israeli tick typhus strain (n = 33, 79%); infection with this species necessitated intensive care for 52% of patients and was associated with a 30% fatality rate. A history of tick bite was rare, found for only 5% of patients; eschar was found in 12%; and leukocytosis was more common than leukopenia. Most (72%) patients resided along the Mediterranean shoreline. For 3 patients, a new Rickettsia variant was identified and had been acquired in eastern, mountainous parts of Israel. One patient had prolonged fever before admission and clinical signs resembling tickborne lymphadenopathy. Our findings suggest that a broad range of Rickettsia species cause spotted fever group rickettsiosis in Israel.

AB - In a multicenter, nationwide, retrospective study of patients hospitalized with spotted fever group rickettsiosis in Israel during 2010–2019, we identified 42 cases, of which 36 were autochthonous. The most prevalent species was the Rickettsia conorii Israeli tick typhus strain (n = 33, 79%); infection with this species necessitated intensive care for 52% of patients and was associated with a 30% fatality rate. A history of tick bite was rare, found for only 5% of patients; eschar was found in 12%; and leukocytosis was more common than leukopenia. Most (72%) patients resided along the Mediterranean shoreline. For 3 patients, a new Rickettsia variant was identified and had been acquired in eastern, mountainous parts of Israel. One patient had prolonged fever before admission and clinical signs resembling tickborne lymphadenopathy. Our findings suggest that a broad range of Rickettsia species cause spotted fever group rickettsiosis in Israel.

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Spotted fever group rickettsioses in Israel, 2010–2019

Abstract

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