Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX

Essam A. Assali, Israel Sekler

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

NCLX, the mitochondrial Na+/Ca2+ transporter is a key player in Ca2+ signaling. However, its role in Na+ signaling is poorly understood. In this review we focus on Na+ signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na+ influx into mitochondria.

Original languageEnglish
Article number102416
JournalCell Calcium
Volume97
DOIs
StatePublished - 1 Jul 2021

Keywords

  • Hypoxia
  • Ischemia
  • Mitochondrial Ca efflux
  • NCLX
  • Na signaling

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na+ signaling mediated by NCLX'. Together they form a unique fingerprint.

Cite this