Stability of CSF metabolites measured by proton NMR

J. Levine; K. Panchalingam; R. J. McClure; S. Gershon; J. W. Pettegrew

doi:10.1007/s007020070064

Stability of CSF metabolites measured by proton NMR

J. Levine, K. Panchalingam, R. J. McClure, S. Gershon, J. W. Pettegrew

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26 Scopus citations

Abstract

Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (> 50%) and increase in lactate, glutamine, creatine, and creatinine levels.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Journal of Neural Transmission
Volume	107
Issue number	7
DOIs	https://doi.org/10.1007/s007020070064
State	Published - 2 Aug 2000

Keywords

Cerebrospinal fluid
Proton NMR

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/s007020070064

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abstract = "Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (> 50%) and increase in lactate, glutamine, creatine, and creatinine levels.",

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AU - Levine, J.

AU - Panchalingam, K.

AU - McClure, R. J.

AU - Gershon, S.

AU - Pettegrew, J. W.

PY - 2000/8/2

Y1 - 2000/8/2

N2 - Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (> 50%) and increase in lactate, glutamine, creatine, and creatinine levels.

AB - Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (> 50%) and increase in lactate, glutamine, creatine, and creatinine levels.

KW - Cerebrospinal fluid

KW - Proton NMR

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JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 7

ER -

Stability of CSF metabolites measured by proton NMR

Abstract

Keywords

ASJC Scopus subject areas

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