Stability of CSF metabolites measured by proton NMR

J. Levine, K. Panchalingam, R. J. McClure, S. Gershon, J. W. Pettegrew

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (> 50%) and increase in lactate, glutamine, creatine, and creatinine levels.

    Original languageEnglish
    Pages (from-to)843-848
    Number of pages6
    JournalJournal of Neural Transmission
    Volume107
    Issue number7
    DOIs
    StatePublished - 2 Aug 2000

    Keywords

    • Cerebrospinal fluid
    • Proton NMR

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Psychiatry and Mental health
    • Biological Psychiatry

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