Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Bradley G. Wagner, Benjamin M. Althouse, Noga Givon-Lavi, Hao Hu, Ron Dagan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

Original languageEnglish
Pages (from-to)5625-5629
Number of pages5
JournalVaccine
Volume37
Issue number37
DOIs
StatePublished - 3 Sep 2019

Keywords

  • Pneumococcal carriage
  • Pneumococcal conjugate vaccine
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology (all)
  • Veterinary (all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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