Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Bradley G. Wagner; Benjamin M. Althouse; Noga Givon-Lavi; Hao Hu; Ron Dagan

doi:10.1016/j.vaccine.2019.07.077

Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Bradley G. Wagner
, Benjamin M. Althouse
, Noga Givon-Lavi
, Hao Hu
, Ron Dagan

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

Original language	English
Pages (from-to)	5625-5629
Number of pages	5
Journal	Vaccine
Volume	37
Issue number	37
DOIs	https://doi.org/10.1016/j.vaccine.2019.07.077
State	Published - 3 Sep 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Pneumococcal carriage
Pneumococcal conjugate vaccine
Streptococcus pneumoniae

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2019.07.077

Cite this

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title = "Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era",

abstract = "Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35\% (95\% CI: 26, 44) and 19\% (95\% CI: 15, 24), respectively in Jewish and 70\% (95\% CI, 62, 77) and 41\% (95\% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.",

keywords = "Pneumococcal carriage, Pneumococcal conjugate vaccine, Streptococcus pneumoniae",

author = "Wagner, \{Bradley G.\} and Althouse, \{Benjamin M.\} and Noga Givon-Lavi and Hao Hu and Ron Dagan",

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doi = "10.1016/j.vaccine.2019.07.077",

language = "English",

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TY - JOUR

T1 - Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

AU - Wagner, Bradley G.

AU - Althouse, Benjamin M.

AU - Givon-Lavi, Noga

AU - Hu, Hao

AU - Dagan, Ron

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

AB - Streptococcus pneumoniae (SP) nasopharyngeal carriage studies are important to understand SP circulation prior to implementation of vaccination programs. It is generally not known how stable these carriage rates are over time. Carriage studies were conducted in Southern Israel during a decade preceding Pneumococcal Conjugate Vaccine (PCV) introduction. We estimated total and vaccine-type SP carriage at 6 months of age to be stable at 35% (95% CI: 26, 44) and 19% (95% CI: 15, 24), respectively in Jewish and 70% (95% CI, 62, 77) and 41% (95% CI: 38, 45) in Bedouin populations. The stability of carriage rates in two disparate populations over 10 years suggests a single survey may be sufficient to characterize pneumococcal carriage pre-PCV.

KW - Pneumococcal carriage

KW - Pneumococcal conjugate vaccine

KW - Streptococcus pneumoniae

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DO - 10.1016/j.vaccine.2019.07.077

M3 - Article

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JO - Vaccine

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ER -

Stable dynamics of pneumococcal carriage over a decade in the pre-PCV era

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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