Standing of giants shoulders the story of the mitochondrial Na+Ca2+ exchanger

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16 Scopus citations

Abstract

It is now the 40th anniversary of the Journal of Molecular and Cellular Cardiology paper by Ernesto Carafoli and colleagues. This seminal study described for the first time mitochondrial Ca2+ extrusion and its coupling to Na+. This short review will describe the profound impact that this work had on mitochondrial signaling and the cross talk between the mitochondria, the ER, and the plasma membrane. It will further tell how the functional identification and in particular its unique cation selectivity to both Li+ and Na+ eventually contributed to the identification of the mitochondrial Na+/Ca2+ exchanger gene NCLX many years later. The last part will describe how molecular tools derived from NCLX identification are used to study the novel physiological aspects of Ca2+ signaling.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume460
Issue number1
DOIs
StatePublished - 19 May 2015

Keywords

  • MCU
  • Mitochondrial Ca signaling
  • NCLX
  • Na signaling

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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