Statins, inflammation, and sepsis: Hypothesis

Yaniv Almog

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

Original languageEnglish
Pages (from-to)740-743
Number of pages4
JournalChest
Volume124
Issue number2
DOIs
StatePublished - 1 Aug 2003
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Apoptosis
  • Nitric oxide
  • Sepsis
  • Statins

Fingerprint

Dive into the research topics of 'Statins, inflammation, and sepsis: Hypothesis'. Together they form a unique fingerprint.

Cite this