Abstract
Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.
Original language | English |
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Pages (from-to) | 740-743 |
Number of pages | 4 |
Journal | Chest |
Volume | 124 |
Issue number | 2 |
DOIs | |
State | Published - 1 Aug 2003 |
Keywords
- Anti-inflammatory
- Apoptosis
- Nitric oxide
- Sepsis
- Statins
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine