Statins, inflammation, and sepsis: Hypothesis

Yaniv Almog

    Research output: Contribution to journalArticlepeer-review

    99 Scopus citations

    Abstract

    Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

    Original languageEnglish
    Pages (from-to)740-743
    Number of pages4
    JournalChest
    Volume124
    Issue number2
    DOIs
    StatePublished - 1 Aug 2003

    Keywords

    • Anti-inflammatory
    • Apoptosis
    • Nitric oxide
    • Sepsis
    • Statins

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Critical Care and Intensive Care Medicine
    • Cardiology and Cardiovascular Medicine

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