Statins, inflammation, and sepsis: Hypothesis

Yaniv Almog

doi:10.1378/chest.124.2.740

Statins, inflammation, and sepsis: Hypothesis

Yaniv Almog

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

Original language	English
Pages (from-to)	740-743
Number of pages	4
Journal	Chest
Volume	124
Issue number	2
DOIs	https://doi.org/10.1378/chest.124.2.740
State	Published - 1 Aug 2003

Keywords

Anti-inflammatory
Apoptosis
Nitric oxide
Sepsis
Statins

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1378/chest.124.2.740

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title = "Statins, inflammation, and sepsis: Hypothesis",

abstract = "Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.",

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N2 - Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

AB - Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humeral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

KW - Anti-inflammatory

KW - Apoptosis

KW - Nitric oxide

KW - Sepsis

KW - Statins

UR - https://www.scopus.com/pages/publications/0042231088

U2 - 10.1378/chest.124.2.740

DO - 10.1378/chest.124.2.740

M3 - Article

C2 - 12907568

AN - SCOPUS:0042231088

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SP - 740

EP - 743

JO - Chest

JF - Chest

IS - 2

ER -

Statins, inflammation, and sepsis: Hypothesis

Abstract

Keywords

ASJC Scopus subject areas

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