Statistical survey of hydrogen-bond motifs in crystallography special symmetry positions, and the influence of chirality of molecules in the crystal on the formation of hydrogen-bond ring motifs

A statistical survey was carried out to examine the connection between hydrogen-bond ring motifs (synthons) and cristallographie special symmetry positions. In the first part, the probability of common hydrogen-bond ring motifs to occupy specific crystallographic symmetry positions of inversion centers, rotation axes and mirror planes was examined. In the second part the probability of the occurrence of hydrogenbond ring motifs was compared between crystals of chiral molecules (which cannot form inversion or mirror symmetry) to crystals of achiral molecules and racemic crystals. The results show that the crystallographic inversion center is a very significant component in the formation of hydrogen-bond ring motifs.