Statistically enhanced promiscuity of structurally correlated patterns

D. B. Lukatsky, E. I. Shakhnovich

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We predict that patterns with correlated surface density of atoms have statistically higher promiscuity (ability to bind stronger to an arbitrary pattern) as compared with noncorrelated patterns with the same average surface density. We suggest that this constitutes a generic design principle for highly connected proteins (hubs) in protein interaction networks. We develop an analytical theory for this effect. We show that our key predictions are generic and independent, qualitatively, on the specific form of the interatomic interaction potential, provided it has a finite range.

Original languageEnglish
Article number020901
JournalPhysical Review E
Issue number2
StatePublished - 1 Feb 2008
Externally publishedYes

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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