Stent thrombosis in a patient with high on-treatment platelet reactivity despite ticagrelor treatment

Anees Musallam, Eli I. Lev, Ariel Roguin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We describe, to the best of our knowledge, the first incidence of stent thrombosis in a patient treated with ticagrelor, who exhibited high on-treatment platelet reactivity (HTPR) according to platelet reactivity testing. He was on clopidrogel and tested for platelet reactivity using the VerifyNow P2Y12 assay. The test showed a PRU of 249 and only 12% platelet inhibition. The patient was then switched to ticagrelor, with a loading dose of 180 mg given. The patient had stent thrombosis three weeks later with an acute myocardial infarction (MI). The patient had good platelet inhibition when started on Ticagrelor treatment (PRU=33), but had HTPR when the stent thrombosis occurred three weeks later (PRU=339).

Original languageEnglish
Pages (from-to)85-87
Number of pages3
JournalEuropean Heart Journal: Acute Cardiovascular Care
Volume4
Issue number1
DOIs
StatePublished - 1 Feb 2015
Externally publishedYes

Keywords

  • Stent thrombosis
  • anti-platelet
  • safety

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