Stereochemical Requirements for Cannabinoid Activity

R. Mechoulam, N. Lander, T. H. Varkony, I. Kimmel, O. Becker, Z. Ben-Zvi, H. Edery, G. Porath

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Several pairs of cannabinoid isomers were synthesized and tested for pyschotropic activity in rhesus monkeys. Two regularities were observed: (a) In the absence of the other substituents, the equatorial stereochemistry of the substituent at C-1 determines activity, (b) Two groups of THC-type cannabinoids which differ only in that the chemical groupings in one of them at C-1, C-2 are situated at C-1, C-6 in the other (but retain their stereochemistry) have almost equivalent pyschotropic activity.

Original languageEnglish
Pages (from-to)1068-1072
Number of pages5
JournalJournal of Medicinal Chemistry
Volume23
Issue number10
DOIs
StatePublished - 1 Oct 1980
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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