Stereotactic ablative body radiation for stage i lung cancer in israel: A retrospective single-center report

Sarit Appel, Yaacov R. Lawrence, Jeffery Goldstein, Raphael M. Pfeffer, Ilana Weiss, Tatiana Rabin, Shira Felder, Maoz Ben-Ayun, Lev Tzvang, Dror Alezra, David Simansky, Alon Ben-Nun, Jair Bar, Zvi Symon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Stereotactic ablative radiation therapy (SABR) is the application of a very high radiation dose to a small treatment volume. It is the new standard of care in medically inoperable early-stage lung cancer. Objectives: To report the outcomes of SABR in stage I lung cancer at Sheba Medical Center since its introduction in 2009. Methods: We conducted a retrospective chart review of patients with stage I lung cancer treated during the period 2009–2015. Survival status was retrieved from the electronic medical records and confirmed with the national registry. Local failure was defined as increased FDG uptake on PETCT scan within a 2 cm radius of the treated region. Toxicity was estimated from medical records and graded according to common toxicity criteria for adverse events (CTCAE) version 4.03. Overall survival and local control were estimated by the Kaplan-Meier method. Results: During the study period 114 patients were treated for 122 stage I lung cancer lesions. Median follow-up time was 27 months (range 8.2–69.5 months), median age was 76 years. Eighty-two percent of the tumors were stage IA (size ≤ 3 cm). Median survival was 46 months; estimated 3 year overall survival was 59% (95%CI 47–69%) and local control was 88% (95%CI 78–94%). Toxicity included chest wall pain in 8.4% of patients, rib fracture in 0.9%, grade 1–2 pneumonitis in 12%, grade 3 in 12% and grade 5 (death) in 0.9%. Conclusions: SABR has been successfully implemented at Sheba Medical Center for the treatment of stage I lung cancer in inoperable patients. It is associated with excellent local control, minor toxicity and an acceptable overall survival.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalIsrael Medical Association Journal
Volume19
Issue number1
StatePublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Radiation therapy
  • Stage i lung cancer
  • Stereotactic ablative radiation therapy (SABR)
  • Stereotactic body radiation therapy (SBRT)

Fingerprint

Dive into the research topics of 'Stereotactic ablative body radiation for stage i lung cancer in israel: A retrospective single-center report'. Together they form a unique fingerprint.

Cite this