Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Neli Boneva, Yasmine Hamra-Amitay, Itzhak Wirguin, Talma Brenner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The neuromuscular weakness associated with myasthenia gravis (MG) can be transiently relieved by pharmacological inhibitors of acetylcholinesterase (AChE). Here, we expand the anticholinesterase repertoire to include 2′-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA (EN101). Using stimulated-single fiber electromyography, we show that EN101 treatment of rats with experimental autoimmune myasthenia gravis (EAMG), improved the mean consecutive difference (MCD) and blocking for 24 h. This treatment was more efficient than pyridostigmine and was accompanied by marked improvement in stamina and clinical profile.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalNeuroscience Research
Volume55
Issue number1
DOIs
StatePublished - 1 May 2006
Externally publishedYes

Keywords

  • Acetylcholinesterase inhibition
  • Anti-sense treatment
  • Experimental autoimmune myasthenia gravis
  • Myasthenia gravis
  • Stimulated-single fiber electromyography

ASJC Scopus subject areas

  • Neuroscience (all)

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