Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Neli Boneva; Yasmine Hamra-Amitay; Itzhak Wirguin; Talma Brenner

doi:10.1016/j.neures.2006.01.003

Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Neli Boneva, Yasmine Hamra-Amitay, Itzhak Wirguin, Talma Brenner

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The neuromuscular weakness associated with myasthenia gravis (MG) can be transiently relieved by pharmacological inhibitors of acetylcholinesterase (AChE). Here, we expand the anticholinesterase repertoire to include 2′-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA (EN101). Using stimulated-single fiber electromyography, we show that EN101 treatment of rats with experimental autoimmune myasthenia gravis (EAMG), improved the mean consecutive difference (MCD) and blocking for 24 h. This treatment was more efficient than pyridostigmine and was accompanied by marked improvement in stamina and clinical profile.

Original language	English
Pages (from-to)	40-44
Number of pages	5
Journal	Neuroscience Research
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/j.neures.2006.01.003
State	Published - 1 May 2006

Keywords

Acetylcholinesterase inhibition
Anti-sense treatment
Experimental autoimmune myasthenia gravis
Myasthenia gravis
Stimulated-single fiber electromyography

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neures.2006.01.003

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title = "Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis",

abstract = "The neuromuscular weakness associated with myasthenia gravis (MG) can be transiently relieved by pharmacological inhibitors of acetylcholinesterase (AChE). Here, we expand the anticholinesterase repertoire to include 2′-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA (EN101). Using stimulated-single fiber electromyography, we show that EN101 treatment of rats with experimental autoimmune myasthenia gravis (EAMG), improved the mean consecutive difference (MCD) and blocking for 24 h. This treatment was more efficient than pyridostigmine and was accompanied by marked improvement in stamina and clinical profile.",

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AU - Hamra-Amitay, Yasmine

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AU - Brenner, Talma

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AB - The neuromuscular weakness associated with myasthenia gravis (MG) can be transiently relieved by pharmacological inhibitors of acetylcholinesterase (AChE). Here, we expand the anticholinesterase repertoire to include 2′-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA (EN101). Using stimulated-single fiber electromyography, we show that EN101 treatment of rats with experimental autoimmune myasthenia gravis (EAMG), improved the mean consecutive difference (MCD) and blocking for 24 h. This treatment was more efficient than pyridostigmine and was accompanied by marked improvement in stamina and clinical profile.

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Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Abstract

Keywords

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