Stimulation of prostaglandin E production by concanavalin A in isolated graafian follicles

B. Strulovici; Y. Weinstein; U. Zor

doi:10.1016/0090-6980(81)90232-X

Stimulation of prostaglandin E production by concanavalin A in isolated graafian follicles

B. Strulovici, Y. Weinstein, U. Zor

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Addition of Concanavalin A (con A) to isolated rat Graafian follicles induced prostaglandin E (PGE) production after 2 h of incubation. PGE synthesis continued throughout 24 h culture period. Cyclic AMP accumulation was noted after 6 h of incubation with Con A. Aspirin, indomethacin and flufenamate prevented both the stimulation of PGE production and of cyclic AMP accumulation by Con A; antibodies to PGE prevented the cyclic AMP production. These studies indicate that the interaction of Con A with the follicle results in PGE production. It seems that besides the known pathway for the induction of PGE synthesis in the ovarian follicle, via elevation of intracellular cyclic AMP, an additional pathway, via an external signal which is independent of cyclic AMP exists.

Original language	English
Pages (from-to)	751-757
Number of pages	7
Journal	Prostaglandins
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/0090-6980(81)90232-X
State	Published - 1 Jan 1981
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

Access to Document

10.1016/0090-6980(81)90232-X

Cite this

@article{c329e7d519384f9286ae06aa7a3c8b56,

title = "Stimulation of prostaglandin E production by concanavalin A in isolated graafian follicles",

abstract = "Addition of Concanavalin A (con A) to isolated rat Graafian follicles induced prostaglandin E (PGE) production after 2 h of incubation. PGE synthesis continued throughout 24 h culture period. Cyclic AMP accumulation was noted after 6 h of incubation with Con A. Aspirin, indomethacin and flufenamate prevented both the stimulation of PGE production and of cyclic AMP accumulation by Con A; antibodies to PGE prevented the cyclic AMP production. These studies indicate that the interaction of Con A with the follicle results in PGE production. It seems that besides the known pathway for the induction of PGE synthesis in the ovarian follicle, via elevation of intracellular cyclic AMP, an additional pathway, via an external signal which is independent of cyclic AMP exists.",

author = "B. Strulovici and Y. Weinstein and U. Zor",

note = "Funding Information: The work was supported by a grant (to Professor H.R. Lindner), from the Ford Foundation and the Population Council, Inc., N.Y. Mr. S. Yosef for devoted animal care; and Mrs. M. Kopelowitz for the typing of the manuscript.",

year = "1981",

month = jan,

day = "1",

doi = "10.1016/0090-6980(81)90232-X",

language = "English",

volume = "21",

pages = "751--757",

journal = "Prostaglandins",

issn = "0090-6980",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Stimulation of prostaglandin E production by concanavalin A in isolated graafian follicles

AU - Strulovici, B.

AU - Weinstein, Y.

AU - Zor, U.

N1 - Funding Information: The work was supported by a grant (to Professor H.R. Lindner), from the Ford Foundation and the Population Council, Inc., N.Y. Mr. S. Yosef for devoted animal care; and Mrs. M. Kopelowitz for the typing of the manuscript.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Addition of Concanavalin A (con A) to isolated rat Graafian follicles induced prostaglandin E (PGE) production after 2 h of incubation. PGE synthesis continued throughout 24 h culture period. Cyclic AMP accumulation was noted after 6 h of incubation with Con A. Aspirin, indomethacin and flufenamate prevented both the stimulation of PGE production and of cyclic AMP accumulation by Con A; antibodies to PGE prevented the cyclic AMP production. These studies indicate that the interaction of Con A with the follicle results in PGE production. It seems that besides the known pathway for the induction of PGE synthesis in the ovarian follicle, via elevation of intracellular cyclic AMP, an additional pathway, via an external signal which is independent of cyclic AMP exists.

AB - Addition of Concanavalin A (con A) to isolated rat Graafian follicles induced prostaglandin E (PGE) production after 2 h of incubation. PGE synthesis continued throughout 24 h culture period. Cyclic AMP accumulation was noted after 6 h of incubation with Con A. Aspirin, indomethacin and flufenamate prevented both the stimulation of PGE production and of cyclic AMP accumulation by Con A; antibodies to PGE prevented the cyclic AMP production. These studies indicate that the interaction of Con A with the follicle results in PGE production. It seems that besides the known pathway for the induction of PGE synthesis in the ovarian follicle, via elevation of intracellular cyclic AMP, an additional pathway, via an external signal which is independent of cyclic AMP exists.

UR - http://www.scopus.com/inward/record.url?scp=0019566322&partnerID=8YFLogxK

U2 - 10.1016/0090-6980(81)90232-X

DO - 10.1016/0090-6980(81)90232-X

M3 - Article

AN - SCOPUS:0019566322

SN - 0090-6980

VL - 21

SP - 751

EP - 757

JO - Prostaglandins

JF - Prostaglandins

IS - 5

ER -

Stimulation of prostaglandin E production by concanavalin A in isolated graafian follicles

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this