Stimulation of prostaglandin output from rat stomach by hypertonic solutions

Georges Assouline; Valentina Leibson; Abraham Danon

doi:10.1016/0014-2999(77)90073-5

Stimulation of prostaglandin output from rat stomach by hypertonic solutions

Georges Assouline, Valentina Leibson, Abraham Danon

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline-hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	European Journal of Pharmacology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(77)90073-5
State	Published - 1 Aug 1977

Keywords

Hypertonic solutions
Prostaglandins
Stomach

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(77)90073-5

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abstract = "A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline-hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.",

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author = "Georges Assouline and Valentina Leibson and Abraham Danon",

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AU - Leibson, Valentina

AU - Danon, Abraham

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N2 - A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline-hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.

AB - A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline-hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.

KW - Hypertonic solutions

KW - Prostaglandins

KW - Stomach

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DO - 10.1016/0014-2999(77)90073-5

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JO - European Journal of Pharmacology

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ER -

Stimulation of prostaglandin output from rat stomach by hypertonic solutions

Abstract

Keywords

ASJC Scopus subject areas

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