Stimulation of prostaglandin output from rat stomach by hypertonic solutions

Georges Assouline, Valentina Leibson, Abraham Danon

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline-hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalEuropean Journal of Pharmacology
Volume44
Issue number3
DOIs
StatePublished - 1 Aug 1977

Keywords

  • Hypertonic solutions
  • Prostaglandins
  • Stomach

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