Stimulus Dependent Dynamic Reorganization of the Human Face Processing Network

Gideon Rosenthal, Olaf Sporns, Galia Avidan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Using the "face inversion effect", a hallmark of face perception, we examined network mechanisms supporting face representation by tracking functional magnetic resonance imaging (fMRI) stimulus-dependent dynamic functional connectivity within and between brain networks associated with the processing of upright and inverted faces. We developed a novel approach adapting the general linear model (GLM) framework classically used for univariate fMRI analysis to capture stimulus-dependent fMRI dynamic connectivity of the face network. We show that under the face inversion manipulation, the face and non-face networks have complementary roles that are evident in their stimulus-dependent dynamic connectivity patterns as assessed by network decomposition into components or communities. Moreover, we show that connectivity patterns are associated with the behavioral face inversion effect. Thus, we establish "a network-level signature" of the face inversion effect and demonstrate how a simple physical transformation of the face stimulus induces a dramatic functional reorganization across related brain networks. Finally, we suggest that the dynamic GLM network analysis approach, developed here for the face network, provides a general framework for modeling the dynamics of blocked stimulus-dependent connectivity experimental designs and hence can be applied to a host of neuroimaging studies.

Original languageEnglish
Pages (from-to)4823-4834
Number of pages12
JournalCerebral Cortex
Volume27
Issue number10
DOIs
StatePublished - 1 Oct 2017

Keywords

  • dynamic connectivity
  • fMRI
  • face processing
  • functional connectivity
  • network analysis

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