Stoichiometric variation in two molecular salts of the anti-tuberculosis drug isoniazid with 2-butynoic acid

  • Thabang J. Chiya
  • , Andreas Lemmerer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The supramolecular reagent isoniazid is a molecule capable of undergoing a number of different heteromeric interactions to form neutral co-crystals. By choosing a suitably acidic carboxylic acid molecule, we have been able to form two molecular salts by altering the ratio of the two reactant molecules by both solution crystallization and mechanochemical means. The two stoichiometric salts are formed by using both similar and different hydrogen bonded interactions to those encountered previously in co-crystals.

Original languageEnglish
Pages (from-to)5124-5127
Number of pages4
JournalCrystEngComm
Volume14
Issue number16
DOIs
StatePublished - 21 Aug 2012
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics

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