Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro

Medicine & Life Sciences

• Apigenin 100%
• Nanoparticles 63%
• Melanoma 59%
• Therapeutic Uses 58%
• DNA 39%
• Skin 39%
• In Vitro Techniques 31%
• Photolysis 14%
• Glutathione Reductase 12%
• Caspase 9 11%
• Cytochromes c 11%
• DNA Fragmentation 10%
• Mitochondrial Membrane Potential 10%
• Particle Size 10%
• Ultraviolet Rays 10%
• Flavonoids 10%
• Transmission Electron Microscopy 10%
• Adenosine Triphosphatases 10%
• Adenosine Diphosphate 10%
• Drug Liberation 9%
• Confocal Microscopy 9%
• Milk 9%
• Superoxide Dismutase 9%
• Evaluation Studies 9%
• DNA Damage 8%
• Adenosine Triphosphate 7%
• Antioxidants 7%
• Apoptosis 6%
• Enzymes 5%
• Neoplasms 3%
• Therapeutics 1%

Chemical Compounds

• Nanoparticle 35%
• Apigenin 26%
• Encapsulation 17%
• Confocal Microscopy 11%
• ADP 10%
• Antiproliferative 10%
• Flavonoid 9%
• Photodegradation 9%
• Zeta Potential 8%
• Marker 8%
• Fragmentation 8%
• Enzyme Activity 8%
• Antioxidant Agent 7%
• Compound Mobility 7%
• Gibbs Free Energy 7%
• Cleavage 6%
• Transmission Electron Microscopy 6%
• Volume 5%
• Drug 5%