Streptococcus pneumoniae serotype 6C in Costa Rican children with otitis media before introduction of the 7-valent pneumococcal conjugated vaccine into the national immunization program

Arturo Abdelnour, Carolina Soley, Silvia Guevara, Nurith Porat, Ron Dagan, Adriano Arguedas

Research output: Contribution to journalArticlepeer-review

Abstract

During the years 1999 through 2008 middle ear fluid (MEF) and nasopharyngeal/oropharyngeal (NP/OP) samples were obtained from Costa Rican children with otitis media (OM). Streptococcus pneumoniae was identified and serotyped according to standard procedures. A total of 1,389 MEF isolates were collected, of which 353 (25%) were S. pneumoniae. Serotyping was performed in 286/353 (81%) isolates, of which 40 (14%) were serogroup 6: serotype 6A (10/40; 25%), 6B (27/40; 67%) and 6C (3/40; 8%). Among 755 NP/OP S. pneumoniae isolated, 537 (71%) were serotyped and serogroup 6 was identified in 112 (21%) isolates: 6A (24/112; 21%), 6B (78/112; 70%), and 6C (10/112; 9%). Twenty percent, 86% and 0% of serotypes 6A, 6B and 6C isolated from the MEF, respectively, were penicillin non-susceptible (MIC ≥ 0.06 μg/mL) and among the NP/OP isolates, 25%, 17.9% and 10%, respectively, were penicillin non-susceptible. Our results show that in Costa Rican children with OM, S. pneumoniae serotype 6C is an infrequent cause of OM and is sporadically found in NP/OP samples.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalJournal of Pediatric Infectious Diseases
Volume6
Issue number4
DOIs
StatePublished - 1 Dec 2011
Externally publishedYes

Keywords

  • Streptococcus pneumoniae
  • otitis media
  • serotypes
  • vaccines

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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