TY - JOUR
T1 - Streptococcus pneumoniae serotype 6C in Costa Rican children with otitis media before introduction of the 7-valent pneumococcal conjugated vaccine into the national immunization program
AU - Abdelnour, Arturo
AU - Soley, Carolina
AU - Guevara, Silvia
AU - Porat, Nurith
AU - Dagan, Ron
AU - Arguedas, Adriano
PY - 2011/12/1
Y1 - 2011/12/1
N2 - During the years 1999 through 2008 middle ear fluid (MEF) and nasopharyngeal/oropharyngeal (NP/OP) samples were obtained from Costa Rican children with otitis media (OM). Streptococcus pneumoniae was identified and serotyped according to standard procedures. A total of 1,389 MEF isolates were collected, of which 353 (25%) were S. pneumoniae. Serotyping was performed in 286/353 (81%) isolates, of which 40 (14%) were serogroup 6: serotype 6A (10/40; 25%), 6B (27/40; 67%) and 6C (3/40; 8%). Among 755 NP/OP S. pneumoniae isolated, 537 (71%) were serotyped and serogroup 6 was identified in 112 (21%) isolates: 6A (24/112; 21%), 6B (78/112; 70%), and 6C (10/112; 9%). Twenty percent, 86% and 0% of serotypes 6A, 6B and 6C isolated from the MEF, respectively, were penicillin non-susceptible (MIC ≥ 0.06 μg/mL) and among the NP/OP isolates, 25%, 17.9% and 10%, respectively, were penicillin non-susceptible. Our results show that in Costa Rican children with OM, S. pneumoniae serotype 6C is an infrequent cause of OM and is sporadically found in NP/OP samples.
AB - During the years 1999 through 2008 middle ear fluid (MEF) and nasopharyngeal/oropharyngeal (NP/OP) samples were obtained from Costa Rican children with otitis media (OM). Streptococcus pneumoniae was identified and serotyped according to standard procedures. A total of 1,389 MEF isolates were collected, of which 353 (25%) were S. pneumoniae. Serotyping was performed in 286/353 (81%) isolates, of which 40 (14%) were serogroup 6: serotype 6A (10/40; 25%), 6B (27/40; 67%) and 6C (3/40; 8%). Among 755 NP/OP S. pneumoniae isolated, 537 (71%) were serotyped and serogroup 6 was identified in 112 (21%) isolates: 6A (24/112; 21%), 6B (78/112; 70%), and 6C (10/112; 9%). Twenty percent, 86% and 0% of serotypes 6A, 6B and 6C isolated from the MEF, respectively, were penicillin non-susceptible (MIC ≥ 0.06 μg/mL) and among the NP/OP isolates, 25%, 17.9% and 10%, respectively, were penicillin non-susceptible. Our results show that in Costa Rican children with OM, S. pneumoniae serotype 6C is an infrequent cause of OM and is sporadically found in NP/OP samples.
KW - Streptococcus pneumoniae
KW - otitis media
KW - serotypes
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=84859334111&partnerID=8YFLogxK
U2 - 10.3233/JPI-2012-0331
DO - 10.3233/JPI-2012-0331
M3 - Article
AN - SCOPUS:84859334111
SN - 1305-7707
VL - 6
SP - 243
EP - 246
JO - Journal of Pediatric Infectious Diseases
JF - Journal of Pediatric Infectious Diseases
IS - 4
ER -