Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation

Marta Aramburu-Núñez; Antía Custodia; María Pérez-Mato; Ramón Iglesias-Rey; Francisco Campos; José Castillo; Alberto Ouro; Daniel Romaus-Sanjurjo; Tomás Sobrino

doi:10.3390/ijms23073747

Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation

Marta Aramburu-Núñez, Antía Custodia, María Pérez-Mato, Ramón Iglesias-Rey, Francisco Campos, José Castillo, Alberto Ouro, Daniel Romaus-Sanjurjo, Tomás Sobrino

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia.

Original language	English
Article number	3747
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	7
DOIs	https://doi.org/10.3390/ijms23073747
State	Published - 1 Apr 2022
Externally published	Yes

Keywords

endothelial cell
eukaryotic initiation factor 2
eukaryotic initiation factor 4F
hippocampus
ischemia
neuron
stress granules
stroke

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms23073747

Cite this

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title = "Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation",

abstract = "Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER{\textquoteright}s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia.",

keywords = "endothelial cell, eukaryotic initiation factor 2, eukaryotic initiation factor 4F, hippocampus, ischemia, neuron, stress granules, stroke",

author = "Marta Aramburu-N{\'u}{\~n}ez and Ant{\'i}a Custodia and Mar{\'i}a P{\'e}rez-Mato and Ram{\'o}n Iglesias-Rey and Francisco Campos and Jos{\'e} Castillo and Alberto Ouro and Daniel Romaus-Sanjurjo and Tom{\'a}s Sobrino",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = apr,

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doi = "10.3390/ijms23073747",

language = "English",

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TY - JOUR

T1 - Stress Granules and Acute Ischemic Stroke

T2 - Beyond mRNA Translation

AU - Aramburu-Núñez, Marta

AU - Custodia, Antía

AU - Pérez-Mato, María

AU - Iglesias-Rey, Ramón

AU - Campos, Francisco

AU - Castillo, José

AU - Ouro, Alberto

AU - Romaus-Sanjurjo, Daniel

AU - Sobrino, Tomás

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia.

AB - Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia.

KW - endothelial cell

KW - eukaryotic initiation factor 2

KW - eukaryotic initiation factor 4F

KW - hippocampus

KW - ischemia

KW - neuron

KW - stress granules

KW - stroke

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U2 - 10.3390/ijms23073747

DO - 10.3390/ijms23073747

M3 - Review article

C2 - 35409112

AN - SCOPUS:85127280988

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 7

M1 - 3747

ER -

Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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