Stress-modulated collagen fiber remodeling in a human carotid bifurcation

I. Hariton, G. deBotton, T. C. Gasser, G. A. Holzapfel

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


This work concerns with the implementation of a new stress-driven remodeling model for simulating the overall structure and mechanical behavior of a human carotid bifurcation. By means of an iterative finite element based procedure collagen fiber direction and maximal principal stresses are computed. We find that the predicted fibers' architecture at the cylindrical branches and at the apex of the bifurcation correlates well with histological observations. Some insights about the mechanical response of the sinus bulb and the bifurcation apex are revealed and discussed. The results are compared with other, isotropic and orthotropic, models available in the literature.

Original languageEnglish
Pages (from-to)460-470
Number of pages11
JournalJournal of Theoretical Biology
Issue number3
StatePublished - 7 Oct 2007


  • Carotid artery bifurcation
  • FE analysis
  • Hyperelasticity
  • Remodeling
  • Soft tissues

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


Dive into the research topics of 'Stress-modulated collagen fiber remodeling in a human carotid bifurcation'. Together they form a unique fingerprint.

Cite this