Structural and functional discussion of the tetra-trico-peptide repeat, a protein interaction module

Natalie Zeytuni, Raz Zarivach

Research output: Contribution to journalReview articlepeer-review

253 Scopus citations

Abstract

Tetra-trico-peptide repeat (TPR) domains are found in numerous proteins, where they serve as interaction modules and multiprotein complex mediators. TPRs can be found in all kingdoms of life and regulate diverse biological processes, such as organelle targeting and protein import, vesicle fusion, and biomineralization. This review considers the structural features of TPR domains that permit the great ligand-binding diversity of this motif, given that TPR-interacting partners display variations in both sequence and secondary structure. In addition, tools for predicting TPR-interacting partners are discussed, as are the abilities of TPR domains to serve as protein-protein interaction scaffolds in biotechnology and therapeutics.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalStructure
Volume20
Issue number3
DOIs
StatePublished - 7 Mar 2012

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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