Abstract
(Chemical Equation Presented) Nonnatural interactions: The X-ray crystal structure of a mutant aminoacyl-tRNA synthetase that selectively recognizes para-benozyl-L-phenylalanine has been solved. This structure shows that mutations to the enzyme lead to new hydrophobic binding interactions with the unnatural amino acid, and a loss of specific hydrogen-bonding interactions with tyrosine, without a significant change in the polypeptide backbone conformation.
Original language | English |
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Pages (from-to) | 6073-6075 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 32 |
DOIs | |
State | Published - 27 Aug 2007 |
Externally published | Yes |
Keywords
- Amino acids
- Enzymes
- Hydrophobic interactions
- Photo-cross-linker
- Protein structures
ASJC Scopus subject areas
- Catalysis
- General Chemistry