TY - JOUR
T1 - Structural determinants of intermediate filament mechanics
AU - Kechagia, Zanetta
AU - Eibauer, Matthias
AU - Medalia, Ohad
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Intermediate filaments (IFs) are integral to the cell cytoskeleton, supporting cellular mechanical stability. Unlike other cytoskeletal components, the detailed structure of assembled IFs has yet to be resolved. This review highlights new insights, linking the complex IF hierarchical assembly to their mechanical properties and impact on cellular functions. While we focus on vimentin IFs, we draw comparisons to keratins, showcasing the distinctive structural and mechanical features that underlie their unique mechanical responses.
AB - Intermediate filaments (IFs) are integral to the cell cytoskeleton, supporting cellular mechanical stability. Unlike other cytoskeletal components, the detailed structure of assembled IFs has yet to be resolved. This review highlights new insights, linking the complex IF hierarchical assembly to their mechanical properties and impact on cellular functions. While we focus on vimentin IFs, we draw comparisons to keratins, showcasing the distinctive structural and mechanical features that underlie their unique mechanical responses.
UR - http://www.scopus.com/inward/record.url?scp=85195166910&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2024.102375
DO - 10.1016/j.ceb.2024.102375
M3 - Review article
C2 - 38850681
AN - SCOPUS:85195166910
SN - 0955-0674
VL - 89
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
M1 - 102375
ER -