Structural determinants of intermediate filament mechanics

Zanetta Kechagia, Matthias Eibauer, Ohad Medalia

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Intermediate filaments (IFs) are integral to the cell cytoskeleton, supporting cellular mechanical stability. Unlike other cytoskeletal components, the detailed structure of assembled IFs has yet to be resolved. This review highlights new insights, linking the complex IF hierarchical assembly to their mechanical properties and impact on cellular functions. While we focus on vimentin IFs, we draw comparisons to keratins, showcasing the distinctive structural and mechanical features that underlie their unique mechanical responses.

Original languageEnglish
Article number102375
JournalCurrent Opinion in Cell Biology
Volume89
DOIs
StatePublished - 1 Aug 2024
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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