TY - JOUR
T1 - Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder
T2 - A Scoping Review
AU - Ben-Zion, Ziv
AU - Korem, Nachshon
AU - Fine, Naomi B.
AU - Katz, Sophia
AU - Siddhanta, Megha
AU - Funaro, Melissa C.
AU - Duek, Or
AU - Spiller, Tobias R.
AU - Danböck, Sarah K.
AU - Levy, Ifat
AU - Harpaz-Rotem, Ilan
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Numerous studies have explored the relationship between posttraumatic stress disorder (PTSD) and the hippocampus and the amygdala because both regions are implicated in the disorder's pathogenesis and pathophysiology. Nevertheless, those key limbic regions consist of functionally and cytoarchitecturally distinct substructures that may play different roles in the etiology of PTSD. Spurred by the availability of automatic segmentation software, structural neuroimaging studies of human hippocampal and amygdala subregions have proliferated in recent years. Here, we present a preregistered scoping review of the existing structural neuroimaging studies of the hippocampus and amygdala subregions in adults diagnosed with PTSD. A total of 3513 studies assessing subregion volumes were identified, 1689 of which were screened, and 21 studies were eligible for this review (total N = 2876 individuals). Most studies examined hippocampal subregions and reported decreased CA1, CA3, dentate gyrus, and subiculum volumes in PTSD. Fewer studies investigated amygdala subregions and reported altered lateral, basal, and central nuclei volumes in PTSD. This review further highlights the conceptual and methodological limitations of the current literature and identifies future directions to increase understanding of the distinct roles of hippocampal and amygdalar subregions in posttraumatic psychopathology.
AB - Numerous studies have explored the relationship between posttraumatic stress disorder (PTSD) and the hippocampus and the amygdala because both regions are implicated in the disorder's pathogenesis and pathophysiology. Nevertheless, those key limbic regions consist of functionally and cytoarchitecturally distinct substructures that may play different roles in the etiology of PTSD. Spurred by the availability of automatic segmentation software, structural neuroimaging studies of human hippocampal and amygdala subregions have proliferated in recent years. Here, we present a preregistered scoping review of the existing structural neuroimaging studies of the hippocampus and amygdala subregions in adults diagnosed with PTSD. A total of 3513 studies assessing subregion volumes were identified, 1689 of which were screened, and 21 studies were eligible for this review (total N = 2876 individuals). Most studies examined hippocampal subregions and reported decreased CA1, CA3, dentate gyrus, and subiculum volumes in PTSD. Fewer studies investigated amygdala subregions and reported altered lateral, basal, and central nuclei volumes in PTSD. This review further highlights the conceptual and methodological limitations of the current literature and identifies future directions to increase understanding of the distinct roles of hippocampal and amygdalar subregions in posttraumatic psychopathology.
UR - http://www.scopus.com/inward/record.url?scp=85172179603&partnerID=8YFLogxK
U2 - 10.1016/j.bpsgos.2023.07.001
DO - 10.1016/j.bpsgos.2023.07.001
M3 - Review article
C2 - 38298789
AN - SCOPUS:85172179603
SN - 2667-1743
VL - 4
SP - 120
EP - 134
JO - Biological Psychiatry Global Open Science
JF - Biological Psychiatry Global Open Science
IS - 1
ER -