Structure, chromosome mapping and expression of the murine Fgf-6 gene

O. De Lapeyriere; O. Rosnet; D. Benharroch; F. Raybaud; S. Marchetto; J. Planche; F. Galland; M. G. Mattei; N. G. Copeland; N. A. Jenkins; F. Coulier; D. Birnbaum

Structure, chromosome mapping and expression of the murine Fgf-6 gene

O. De Lapeyriere, O. Rosnet, D. Benharroch, F. Raybaud, S. Marchetto, J. Planche, F. Galland, M. G. Mattei, N. G. Copeland, N. A. Jenkins, F. Coulier, D. Birnbaum

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59 Scopus citations

Abstract

The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 gene products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.

Original language	English
Pages (from-to)	823-831
Number of pages	9
Journal	Oncogene
Volume	5
Issue number	6
State	Published - 27 Jun 1990
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{2e84d2a492874e7a9e97f980ccf731d6,

title = "Structure, chromosome mapping and expression of the murine Fgf-6 gene",

abstract = "The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 gene products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.",

author = "{De Lapeyriere}, O. and O. Rosnet and D. Benharroch and F. Raybaud and S. Marchetto and J. Planche and F. Galland and Mattei, {M. G.} and Copeland, {N. G.} and Jenkins, {N. A.} and F. Coulier and D. Birnbaum",

year = "1990",

month = jun,

day = "27",

language = "English",

volume = "5",

pages = "823--831",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "6",

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TY - JOUR

T1 - Structure, chromosome mapping and expression of the murine Fgf-6 gene

AU - De Lapeyriere, O.

AU - Rosnet, O.

AU - Benharroch, D.

AU - Raybaud, F.

AU - Marchetto, S.

AU - Planche, J.

AU - Galland, F.

AU - Mattei, M. G.

AU - Copeland, N. G.

AU - Jenkins, N. A.

AU - Coulier, F.

AU - Birnbaum, D.

PY - 1990/6/27

Y1 - 1990/6/27

N2 - The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 gene products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.

AB - The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 gene products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.

UR - http://www.scopus.com/inward/record.url?scp=0025315344&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025315344

SN - 0950-9232

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JO - Oncogene

JF - Oncogene

IS - 6

ER -

Structure, chromosome mapping and expression of the murine Fgf-6 gene

Abstract

ASJC Scopus subject areas

UN SDGs

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