Structure of DNA coils in dilute and semidilute solutions

Manish Nepal, Alon Yaniv, Eyal Shafran, Oleg Krichevsky

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We apply scanning fluorescence correlation spectroscopy to study the structure of individual DNA coils in dilute and semidilute solutions. In dilute solutions, over two decades in length, from 0.6 to 46 μm, DNA behave as ideal chains, in agreement with theoretical predictions and in disagreement with prior experiments. In semidilute solutions, up to very high densities, the structures of individual DNA coils are independent of concentration, unlike flexible coils that shrink with increasing density. Our experimental findings are consistent with the marginal solution theory of semiflexible polymers.

Original languageEnglish
Article number058102
JournalPhysical Review Letters
Issue number5
StatePublished - 29 Jan 2013

ASJC Scopus subject areas

  • General Physics and Astronomy


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