Studies In Vitro and in Canine Mesenteric Vessels

J. Polio, J. Hanson, E. Sikuler, G. Vogel, R. Gusberg, R. Fisher, R. J. Groszmann

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The accuracy and reliability of a noninvasive pressure- sensitive capsule for the endoscopic measurement of esophageal varix pressure was evaluated. Capsule pressure was correlated with direct intraluminal pressure measurements. The influence o/vessel wall tension on capsule pressure was also assessed. In vitro studies demonstrated an excellent correlation (r ≥ 0.94; p < 0.001) between the pre~sure obtained with the capsule and intraluminal pressure over a range of vessel diameters and wall thicknesses. In vivo correlation of pressures obtained with the capsule with direct venous pressure measurements was excellent (r = 0.85). However, this correlation decreased with a decrease in vessel diameter (group 1 diameter ≥ 10 mm, r = 0.95; group 2 diameter ≥ 5 mm but < 10 mm, r = 0.75; group 3 diameter ≥ 3 mm but < 5 mm, r = 0.81). This decrease in accuracy was significant (p < 0.001) between group 1 and groups 2 and 3. In vitro and in vivo, capsule pressure variability was significantly greater (p < 0.001) in vessels of smaller diameter. Wall tension significantly influenced capsule pressure (p < 0.05), although this effect was only seen in large “vessels” with a diameter beyond a clinically relevant range. Therefore, despite obtaining technically acceptable capsule pressure measurements in ideal experimental conditions, the accuracy and variability of these measurements are limited by vessel size.

Original languageEnglish
Pages (from-to)1109-1115
Number of pages7
Issue number5
StatePublished - 1 Jan 1987
Externally publishedYes


  • CP
  • EVP
  • IP
  • MVP
  • capsule pressure
  • esophageal varix pressure
  • intraluminal pressure
  • mesenteric vein pressure

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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