STUDIES OF Ca2+ RELEASE FROM SARCOPLASMIC RETICULUM

David H. MacLennan; Varda Shoshan; Donald S. Wood

doi:10.1111/j.1749-6632.1982.tb25769.x

STUDIES OF Ca²⁺ RELEASE FROM SARCOPLASMIC RETICULUM

David H. MacLennan, Varda Shoshan, Donald S. Wood

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Summary Our studies of Ca²⁺ release have shown that three classes of compounds—quercetin, which inhibits Ca²⁺ release by reversal of the Ca²⁺ pump, H⁺ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges‐all have potential in probing the mechanism of Ca²⁺ release from sarcoplasmic reticulum.

Original language	English
Pages (from-to)	470-477
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	402
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.1982.tb25769.x
State	Published - 1 Jan 1982

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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abstract = "Summary Our studies of Ca2+ release have shown that three classes of compounds—quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges‐all have potential in probing the mechanism of Ca2+ release from sarcoplasmic reticulum.",

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N2 - Summary Our studies of Ca2+ release have shown that three classes of compounds—quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges‐all have potential in probing the mechanism of Ca2+ release from sarcoplasmic reticulum.

AB - Summary Our studies of Ca2+ release have shown that three classes of compounds—quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges‐all have potential in probing the mechanism of Ca2+ release from sarcoplasmic reticulum.

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STUDIES OF Ca²⁺ RELEASE FROM SARCOPLASMIC RETICULUM

Abstract

ASJC Scopus subject areas

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