Studies of the effect of auranofin, a new antiarthritic agent, on platelet aggregation

I. Nathan, A. E. Finkelstein, D. T. Walz, A. Dvilansky

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Auranofin (AF), at a concentration of 10 Μg/ml, was found to be a potent inhibitor of ADP-, epinephrine-, or collagen-induced platelet aggregation utilizing platelet-rich plasma obtained from human blood. In contrast, aurothioglucose was less effective than AF in inhibiting epinephrine- or collagen-induced platelet aggregation. The inhibitory effect of AF was more evident on the second phase of aggregation and was a function of drug preincubation time. Compared to platelet-rich plasma, washed platelets were superior for detecting the inhibitory action of AF (≥0.1 Μg/ml) on ADP-induced platelet aggregation. This potent inhibitory action of AF on ADP-induced platelet aggregation was antagonized by dithioerythriol, a potent reducing agent. These results suggest that AF can inhibit both platelet release and aggregation mechanisms which may be relevant to its antiarthritic activity. Further studies are required to elucidate the cellular mechanism by which AF inhibits platelet aggregation.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalInflammation
Volume6
Issue number1
DOIs
StatePublished - 1 Mar 1982

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