Studies on Acute Human Infections Using FTIR Microspectroscopy and Cluster Analysis

Jacov Mordehai, Jagannathan Ramesh, Mahmoud Huleihel, Zahavi Cohen, Oleg Kleiner, Marina Talyshinsky, Vitaly Erukhimovitch, Aviv Cahana, Ahmad Salman, Ranjit Kumar Sahu, Hugo Guterman, Shaul Mordechai

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A novel methodology for the diagnosis of acute infections using FTIR microspectroscopy (FTIR-MSP) data on blood components and cluster analysis is presented. Blood samples were collected from 11 patients suffering from various infections and 16 age-matched healthy human controls. Blood components such as white blood cells, red blood cells, and plasma were isolated using standard procedures and FTIR-MSP of these components was utilized. A cluster analysis of the FTIR spectra was performed. The spectra obtained from the three blood components of patients were different from those of controls. The FTIR spectra of white blood cells from patients suffering infections were significantly different from the controls. Cluster analyses of averaged FTIR-MSP spectra of white blood cells provided 100% classification between patients and healthy controls.

Original languageEnglish
Pages (from-to)494-502
Number of pages9
Issue number4
StatePublished - 1 Mar 2004


  • Blood
  • Cluster analysis
  • Diagnosis
  • FTIR microspectroscopy
  • Infection

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


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