Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

Ufana Riaz; Neetika Singh; Anurakshee Verma; Elham S. Aazam

doi:10.1002/pen.25530

Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

Ufana Riaz, Neetika Singh, Anurakshee Verma, Elham S. Aazam

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.

Original language	English
Pages (from-to)	2628-2639
Number of pages	12
Journal	Polymer Engineering and Science
Volume	60
Issue number	10
DOIs	https://doi.org/10.1002/pen.25530
State	Published - 1 Oct 2020
Externally published	Yes

Keywords

X-ray
clay
composites
drug delivery systems
modification

ASJC Scopus subject areas

Chemistry (all)
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/pen.25530

Cite this

@article{5f885e5b129647988680f596a8bf49dd,

title = "Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents",

abstract = "The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.",

keywords = "X-ray, clay, composites, drug delivery systems, modification",

author = "Ufana Riaz and Neetika Singh and Anurakshee Verma and Aazam, {Elham S.}",

note = "Funding Information: This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah under grant No. (D ‐123 ‐247 ‐1441). The authors, therefore, gratefully acknowledge DSR technical and financial support. Publisher Copyright: {\textcopyright} 2020 Society of Plastics Engineers",

year = "2020",

month = oct,

day = "1",

doi = "10.1002/pen.25530",

language = "English",

volume = "60",

pages = "2628--2639",

journal = "Polymer Engineering and Science",

issn = "0032-3888",

publisher = "John Wiley and Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Studies on conducting polymer intercalated layered double hydroxide nanocomposites

T2 - Antituberculosis drug delivery agents

AU - Riaz, Ufana

AU - Singh, Neetika

AU - Verma, Anurakshee

AU - Aazam, Elham S.

N1 - Funding Information: This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah under grant No. (D ‐123 ‐247 ‐1441). The authors, therefore, gratefully acknowledge DSR technical and financial support. Publisher Copyright: © 2020 Society of Plastics Engineers

PY - 2020/10/1

Y1 - 2020/10/1

N2 - The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.

AB - The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.

KW - X-ray

KW - clay

KW - composites

KW - drug delivery systems

KW - modification

UR - http://www.scopus.com/inward/record.url?scp=85090980161&partnerID=8YFLogxK

U2 - 10.1002/pen.25530

DO - 10.1002/pen.25530

M3 - Article

AN - SCOPUS:85090980161

SN - 0032-3888

VL - 60

SP - 2628

EP - 2639

JO - Polymer Engineering and Science

JF - Polymer Engineering and Science

IS - 10

ER -

Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this