Study of fibrinolytic parameters in different types of polycythemia

G. Lugassy, I. Filin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Polycythemia vera (PV) is a myeloproliferative disorder characterized by thrombotic and, less often, bleeding complications. Many mechanisms have been advanced to explain the occurrence of these complications, none of them satisfactory. We examined a cohort of 27 patients with PV, secondary erythrocytosis, and essential thrombocythemia for coagulation and fibrinolytic parameters, including euglobulin lysis test, D-dimer, and α2 antiplasmin. Ten of the 27 patients developed one or more thrombotic complications during the study. We found no clinical correlation between the studied parameters and the complications. Three patients, one of each group, with elevated serum α2 antiplasmin levels, developed severe arterial or venous thromboses.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalAmerican Journal of Hematology
Volume60
Issue number3
DOIs
StatePublished - 1 Jan 1999

Keywords

  • Fibrinolysis
  • Polycythemia

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