TY - JOUR
T1 - Study of the factors affecting blood viscosity in patients with thromboangiitis obliterans. A preliminary report
AU - Szendro, G.
AU - Golcman, L.
AU - Cristal, N.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Hematocrit values, plasma fibrinogen levels, and erythrocyte deformability are well-recognized factors affecting blood viscosity. We studied the incidence of abnormalities in these factors among 17 patients suffering from thromboangiitis obliterans (Buerger's disease) compared with 14 normal age- and sex-matched control subjects. Hematocrit values and fibrinogen levels were higher, whereas the erythrocyte filterability index was lower among the patients with Buerger's disease (p < 0.001). Incubation of washed erythrocytes from these patients with control plasma of blood type AB produced an improvement of the filterability index (p < 0.005). Our findings suggest that patients suffering from Buerger's disease show, in addition to the well-recognized arterial lesions, an abnormality in the factors affecting blood viscosity. This may contribute to a worsening of the clinical manifestations. Evidence is presented suggesting that a plasmatic factor may be responsible for the impaired erythrocyte filterability.
AB - Hematocrit values, plasma fibrinogen levels, and erythrocyte deformability are well-recognized factors affecting blood viscosity. We studied the incidence of abnormalities in these factors among 17 patients suffering from thromboangiitis obliterans (Buerger's disease) compared with 14 normal age- and sex-matched control subjects. Hematocrit values and fibrinogen levels were higher, whereas the erythrocyte filterability index was lower among the patients with Buerger's disease (p < 0.001). Incubation of washed erythrocytes from these patients with control plasma of blood type AB produced an improvement of the filterability index (p < 0.005). Our findings suggest that patients suffering from Buerger's disease show, in addition to the well-recognized arterial lesions, an abnormality in the factors affecting blood viscosity. This may contribute to a worsening of the clinical manifestations. Evidence is presented suggesting that a plasmatic factor may be responsible for the impaired erythrocyte filterability.
UR - http://www.scopus.com/inward/record.url?scp=0023897586&partnerID=8YFLogxK
U2 - 10.1016/0741-5214(88)90038-9
DO - 10.1016/0741-5214(88)90038-9
M3 - Article
AN - SCOPUS:0023897586
SN - 0741-5214
VL - 7
SP - 759
EP - 762
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 6
ER -