Study of the protective effects of katha (heartwood extract of acacia catechu) in liver damage induced by iron overload

Bibhabasu Hazra, Rhitajit Sarkar, Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study evaluated the ameliorating effect of 70% methanol extract of Acacia catechu heartwood, or Katha (ACME) on liver injury induced by iron overload. Iron overload in mice was caused by intraperitoneal administration of 100 mg/kg iron-dextran. ACME was administered orally for 21 days, starting from the day after the first iron-dextran injection. The biochemical markers of hepatic damage and liver iron, protein carbonyl, and hydroxyproline contents were measured in response to the oral administration of ACME. Apart from those, the release of iron from ferritin by ACME was further assessed to determine the efficiency of ACME as an iron-chelating drug. Treatment with different doses of ACME (50, 100, and 200 mg/kg body weight) showed dose-dependent reductions in liver iron, lipid peroxidation, protein oxidation, liver fibrosis, serum enzymes, and ferritin. The antioxidant enzymes levels were enhanced and the reductive release of ferritin iron increased significantly with gradually increasing concentrations of ACME. These results indicate that ACME has a potent hepatoprotective action against hepatic damage induced by iron overload in mice, probably by ameliorating the antioxidant defense activities and reductively releasing ferritin iron.

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume32
Issue number3
DOIs
StatePublished - 12 Nov 2013
Externally publishedYes

Keywords

  • Acacia cetechu
  • Ferritin
  • Hepatic toxicity
  • Hydroxyproline
  • Iron overload
  • Lipid peroxidation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

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