Successful treatment of chronic erythema nodosum with vitamin B12

Ilia Volkov, Inna Rudoy, Yan Press

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A 38-year-old woman presented with painful lesions on both shins that first appeared a few days earlier. Physical examination revealed multiple red tender nodules on both legs. The patient had been treated with nonsteroidal anti-inflammatory drugs for having a few months without any improvement. The patient was referred to a dermatologist and a rheumatologist, who confirmed our diagnosis of chronic erythema nodosum (EN). She returned to the clinic 3 months later complaining of having numbness in the soles of her feet for a few weeks. Her serum vitamin B12 level was 118 pg/mL (normal range 135 to 911). After 4 weeks of twice weekly injections of vitamin B12 at a dose of 1000 mcg, there was a clear alleviation of the numbness, and the EN completely resolved without evidence of recurrence on follow-up. Because it seems that vitamin B12 caused resolution of EN in this case, we recommend that physicians consider testing for vitamin B12 deficiency in patients with EN.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalJournal of the American Board of Family Medicine
Issue number6
StatePublished - 1 Jan 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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