Sugar-assisted ligation for the synthesis of glycopeptides

Ashraf Brik, Chi Huey Wong

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Chemical synthesis of glycoproteins from readily available materials is a powerful method for obtaining a pure product with full control of its atomic structure. Sugar-assisted ligation (SAL) is an emerging approach that allows the synthesis of a large glycopeptide from two unprotected fragments. Contrary to other ligation methods that are limited to the use of a cysteine residue or depend on external auxiliary, SAL takes advantage of the existing sugars in glycopeptides to promote proximity between the two peptides to facilitate an amide bond formation.

Original languageEnglish
Pages (from-to)5670-5675
Number of pages6
JournalChemistry - A European Journal
Volume13
Issue number20
DOIs
StatePublished - 1 Aug 2007

Keywords

  • Amine capture strategy
  • Chemical ligation
  • Glycopeptides
  • Glycoproteins
  • Removable auxiliarys

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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