Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

Hadas Ganin, Josep Rayo, Neri Amara, Niva Levy, Pnina Krief, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalMedChemComm
Volume4
Issue number1
DOIs
StatePublished - 1 Jan 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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