Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

Hadas Ganin; Josep Rayo; Neri Amara; Niva Levy; Pnina Krief; Michael M. Meijler

doi:10.1039/c2md20196h

Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

Hadas Ganin
, Josep Rayo
, Neri Amara
, Niva Levy
, Pnina Krief
, Michael M. Meijler

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

Original language	English
Pages (from-to)	175-179
Number of pages	5
Journal	MedChemComm
Volume	4
Issue number	1
DOIs	https://doi.org/10.1039/c2md20196h
State	Published - 1 Jan 2013

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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10.1039/c2md20196h

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title = "Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing",

abstract = "Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.",

author = "Hadas Ganin and Josep Rayo and Neri Amara and Niva Levy and Pnina Krief and Meijler, \{Michael M.\}",

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AU - Ganin, Hadas

AU - Rayo, Josep

AU - Amara, Neri

AU - Levy, Niva

AU - Krief, Pnina

AU - Meijler, Michael M.

PY - 2013/1/1

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N2 - Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

AB - Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

UR - https://www.scopus.com/pages/publications/84871813251

U2 - 10.1039/c2md20196h

DO - 10.1039/c2md20196h

M3 - Article

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SN - 2040-2503

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JO - MedChemComm

JF - MedChemComm

IS - 1

ER -

Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

Abstract

ASJC Scopus subject areas

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