TY - JOUR
T1 - Superficial Granulomatous Pyoderma Gangrenosum Involving the Face
T2 - A Case Series of Five Patients and a Review of the Literature
AU - Shavit, Eran
AU - Cecchini, Michael
AU - Limacher, James J.
AU - Walsh, Scott
AU - Wentworth, Ashely
AU - Davis, Mark Denis P.
AU - Alavi, Afsaneh
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful and ulcerating lesions on the skin. It rarely involves the face and is often difficult to diagnose. There are few cases reported in the literature of PG involving the face. Aim: To share our experience with 5 patients in whom the final diagnosis was PG involving the face, and to review the literature. Methods: We report a series of 5 patients with a final diagnosis of PG involving the face and reviewed relevant literature. We searched through PubMed and EMBASE using keywords such as “face” and “pyoderma gangrenosum,” “blastomycosis-like pyoderma gangrenosum, vegetative pyoderma gangrenosum and granulomatous pyoderma gangrenosum.” Results: We report 5 patients (4 females) with pyoderma gangrenosum involving the face. All 5 had a final diagnosis of superficial granulomatous PG. All cases presented with nonhealing facial ulcer most commonly on cheeks and a common histopathology of mixed inflammatory infiltrates, multinucleated giant cells, and plasma cells with some granulomatous inflammation. Conclusions: PG can involve the face, and all 5 of our patients had the superficial granulomatous as the most common form.
AB - Background: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful and ulcerating lesions on the skin. It rarely involves the face and is often difficult to diagnose. There are few cases reported in the literature of PG involving the face. Aim: To share our experience with 5 patients in whom the final diagnosis was PG involving the face, and to review the literature. Methods: We report a series of 5 patients with a final diagnosis of PG involving the face and reviewed relevant literature. We searched through PubMed and EMBASE using keywords such as “face” and “pyoderma gangrenosum,” “blastomycosis-like pyoderma gangrenosum, vegetative pyoderma gangrenosum and granulomatous pyoderma gangrenosum.” Results: We report 5 patients (4 females) with pyoderma gangrenosum involving the face. All 5 had a final diagnosis of superficial granulomatous PG. All cases presented with nonhealing facial ulcer most commonly on cheeks and a common histopathology of mixed inflammatory infiltrates, multinucleated giant cells, and plasma cells with some granulomatous inflammation. Conclusions: PG can involve the face, and all 5 of our patients had the superficial granulomatous as the most common form.
KW - blastomycosis-like PG
KW - facial ulcer
KW - granulomatous pyoderma gangrenosum (GPG)
KW - neutrophilic dermatoses
KW - pyoderma
KW - pyoderma gangrenosum (PG)
UR - http://www.scopus.com/inward/record.url?scp=85100555857&partnerID=8YFLogxK
U2 - 10.1177/1203475420988864
DO - 10.1177/1203475420988864
M3 - Article
C2 - 33541119
AN - SCOPUS:85100555857
SN - 1203-4754
VL - 25
SP - 371
EP - 376
JO - Journal of Cutaneous Medicine and Surgery
JF - Journal of Cutaneous Medicine and Surgery
IS - 4
ER -