Suppression of experimetal autoimmune encephalomyelitis by cannabinoids

Itzhak Wirguin; Raphael Mechoulam; Aviva Breuer; Elli Schezen; Joseph Weidenfeld; Talma Brenner

doi:10.1016/0162-3109(94)90056-6

Suppression of experimetal autoimmune encephalomyelitis by cannabinoids

Itzhak Wirguin, Raphael Mechoulam, Aviva Breuer, Elli Schezen, Joseph Weidenfeld, Talma Brenner

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

The effect of Δ⁸-THC on experimental autoimmune encephalomyelitis (EAE) was examined. Δ⁸-THC is an analogue of Δ⁹-THC, the psychoactive component of marihuana. It is more stable and less psychotropic than Δ⁹-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were incolulated for EAE, and Δ⁸-THC (40 mg/kg) was administered for up to 21 days. Δ⁸-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of Δ⁸-THC only occured on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treate with Δ⁸-THC. These results suggest that suppression of EAE cannabinoids may be related to their effect on corticosterone secretion.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Immunopharmacology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(94)90056-6
State	Published - 1 Jan 1994
Externally published	Yes

Keywords

Cannabinoids
Corticosterone
Experimental autoimmune ecephalomyelitis
HU-211
Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

Pharmacology

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10.1016/0162-3109(94)90056-6

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title = "Suppression of experimetal autoimmune encephalomyelitis by cannabinoids",

abstract = "The effect of Δ8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. Δ8-THC is an analogue of Δ9-THC, the psychoactive component of marihuana. It is more stable and less psychotropic than Δ9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were incolulated for EAE, and Δ8-THC (40 mg/kg) was administered for up to 21 days. Δ8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of Δ8-THC only occured on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treate with Δ8-THC. These results suggest that suppression of EAE cannabinoids may be related to their effect on corticosterone secretion.",

keywords = "Cannabinoids, Corticosterone, Experimental autoimmune ecephalomyelitis, HU-211, Δ-Tetrahydrocannabinol",

author = "Itzhak Wirguin and Raphael Mechoulam and Aviva Breuer and Elli Schezen and Joseph Weidenfeld and Talma Brenner",

note = "Funding Information: Supporteidn part by a grantf romthe Joint Fund of the Hebrew Universitya nd HadassahT. he authors are indebtedt o Mrs. R. Mizrachi-Kol and Mrs. E. Reinharzf or excellentte chnicaal ssistance,",

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doi = "10.1016/0162-3109(94)90056-6",

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AU - Wirguin, Itzhak

AU - Mechoulam, Raphael

AU - Breuer, Aviva

AU - Schezen, Elli

AU - Weidenfeld, Joseph

AU - Brenner, Talma

N1 - Funding Information: Supporteidn part by a grantf romthe Joint Fund of the Hebrew Universitya nd HadassahT. he authors are indebtedt o Mrs. R. Mizrachi-Kol and Mrs. E. Reinharzf or excellentte chnicaal ssistance,

PY - 1994/1/1

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N2 - The effect of Δ8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. Δ8-THC is an analogue of Δ9-THC, the psychoactive component of marihuana. It is more stable and less psychotropic than Δ9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were incolulated for EAE, and Δ8-THC (40 mg/kg) was administered for up to 21 days. Δ8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of Δ8-THC only occured on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treate with Δ8-THC. These results suggest that suppression of EAE cannabinoids may be related to their effect on corticosterone secretion.

AB - The effect of Δ8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. Δ8-THC is an analogue of Δ9-THC, the psychoactive component of marihuana. It is more stable and less psychotropic than Δ9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were incolulated for EAE, and Δ8-THC (40 mg/kg) was administered for up to 21 days. Δ8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of Δ8-THC only occured on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treate with Δ8-THC. These results suggest that suppression of EAE cannabinoids may be related to their effect on corticosterone secretion.

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KW - Corticosterone

KW - Experimental autoimmune ecephalomyelitis

KW - HU-211

KW - Δ-Tetrahydrocannabinol

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SN - 0162-3109

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ER -

Suppression of experimetal autoimmune encephalomyelitis by cannabinoids

Abstract

Keywords

ASJC Scopus subject areas

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