TY - JOUR
T1 - Surface and bulk dissolution properties, and selectivity of DNA-linked nanoparticle assemblies
AU - Lukatsky, D. B.
AU - Frenkel, Daan
N1 - Funding Information:
The authors are grateful to B. Bozorgui, E. Eiser, W. Poon, and T. Schmatko for useful discussions and collaborative work, and to H. Tepper for critical reading of the manuscript and for valuable comments. They thank C.-H. Kiang for sending them the manuscript prior to publication. D.L. also thanks S. Safran for useful discussions. The work of the FOM Institute is part of the research program of FOM and is made possible by financial support from The Netherlands Organization for Scientific Research (NWO).
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Using a simple mean-field model, we analyze the surface and bulk dissolution properties of DNA-linked nanoparticle assemblies. We find that the dissolution temperature and the sharpness of the dissolution profiles increase with the grafting density of the single-stranded DNA "probes" on the surface of colloids. The surface grafting density is controlled by the linker occupation number, in analogy with quantum particles obeying fractional statistics. The dissolution temperature increases logarithmically with the salt concentration. This is in agreement with the experimental findings [R. Jin, G. Wu, Z. Li, C. A. Mirkin, and G. C. Schatz, J. Am. Chem. Soc. 125, 1643 (2003)]. By exploiting the unique phase behavior of DNA-coated colloids, it should be possible to detect multiple "targets" in a single experiment by essentially mapping the DNA base-pair sequence onto the phase behavior of DNA-linked nanoparticle solution.
AB - Using a simple mean-field model, we analyze the surface and bulk dissolution properties of DNA-linked nanoparticle assemblies. We find that the dissolution temperature and the sharpness of the dissolution profiles increase with the grafting density of the single-stranded DNA "probes" on the surface of colloids. The surface grafting density is controlled by the linker occupation number, in analogy with quantum particles obeying fractional statistics. The dissolution temperature increases logarithmically with the salt concentration. This is in agreement with the experimental findings [R. Jin, G. Wu, Z. Li, C. A. Mirkin, and G. C. Schatz, J. Am. Chem. Soc. 125, 1643 (2003)]. By exploiting the unique phase behavior of DNA-coated colloids, it should be possible to detect multiple "targets" in a single experiment by essentially mapping the DNA base-pair sequence onto the phase behavior of DNA-linked nanoparticle solution.
UR - http://www.scopus.com/inward/record.url?scp=21244499755&partnerID=8YFLogxK
U2 - 10.1063/1.1906210
DO - 10.1063/1.1906210
M3 - Article
AN - SCOPUS:21244499755
SN - 0021-9606
VL - 122
JO - Journal of Chemical Physics
JF - Journal of Chemical Physics
IS - 21
M1 - 214904
ER -