Surfactants and fatty alcohol based novel nanovesicles for resveratrol: Process optimization, characterization and evaluation of functional properties in RAW 264.7 macrophage cells

Jaya Sravani Vankayala, Surendra Nath Battula, Ruckmani Kandasamy, Gover Antoniraj Mariya, Magdaline Eljeeva Emerald Franklin, Heartwin Amaladhas Pushpadass, Laxmana Naik Naik

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Resveratrol, a natural polyphenol widely applauded for its cardio-protective and anti-cancer activity, has limited application due to its poor solubility and low bioavailability. Hence, an attempt was made to optimize the preparation of biocompatible resveratrol loaded niosomes (R-niosomes) using non-ionic surfactants and fatty alcohol as stabilizer employing the novel and green method of sonication. R-Niosomes exhibited mean particle size of 108 nm with narrow size distribution (PDI = 0.24) and high zeta potential (−56.8 mV). The niosomes had >80% of resveratrol encapsulated into the vesicles and exhibited controlled release under simulated gastro-intestinal conditions. FTIR, XRD and DSC analyses confirmed successful encapsulation of resveratrol into the vesicles. Assays in macrophage RAW264.7 cell lines showed that R-niosomes had lower cytotoxicity and higher intracellular ROS scavenging activity when compared to resveratrol in its free form. This study demonstrated that nanoencapsulation of resveratrol through niosomes using non-ionic surfactant and fatty alcohol has dramatically improved its solubility and functionality.

Original languageEnglish
Pages (from-to)387-396
Number of pages10
JournalJournal of Molecular Liquids
Volume261
DOIs
StatePublished - 1 Jul 2018
Externally publishedYes

Keywords

  • Fatty alcohol
  • Intracellular ROS scavenging activity
  • MTT assay
  • Nanovesicles
  • Resveratrol

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Surfactants and fatty alcohol based novel nanovesicles for resveratrol: Process optimization, characterization and evaluation of functional properties in RAW 264.7 macrophage cells'. Together they form a unique fingerprint.

Cite this