Surgical intervention in children with Crohn's disease

R. Leonor, K. Jacobson, V. Pinsk, E. Webber, D. A. Lemberg

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Introduction: Crohn's disease (CD) causes chronic inflammation of the gastrointestinal tract leading to extensive medical treatments and surgery with two thirds of patients having surgery over their lifetime. In this study, we reviewed the pediatric population at the British Columbia Children's Hospital diagnosed with CD and examined their demographics and treatments, in particular assessing those who ultimately underwent surgery. Materials and methods: Two hundred and eighty children (median age 11.9 years [CI 11.5-12.28]) diagnosed with CD from January 1994 to December 2003 were included. Demographic data were documented including age, ethnicity, duration of symptoms before diagnosis, treatment to date and surgical parameters. Comparison was made between operative and non-operative patients including involvement of disease, medical treatment, complications and recurrence of disease leading to repeat operations. Results: Fifty-five (19.6%) children had surgical procedures. There was a significant increase in surgery in those patients who had not received immunomodulator therapy before surgery (odds ratio 1.95 [CI 1.02-3.73]). We also observed that those CD patients with extensive small intestinal involvement had lower likelihood of having surgery (odds ratio 0.386 [CI 0.145-1.033]). No significant difference was found between the two groups with regard to age of diagnosis (p = 0.41), duration of symptoms (p = 0.22), gender (p = 0.50) or ethnicity (p = 0.451). Conclusion: There was an increased incidence of surgery in those patients who were not treated with immunomodulator therapy. In addition, children with extensive as opposed to isolated small intestinal disease were less likely to have surgery in childhood.

Original languageEnglish
Pages (from-to)1037-1041
Number of pages5
JournalInternational Journal of Colorectal Disease
Issue number9
StatePublished - 1 Sep 2007
Externally publishedYes


  • 6-MP
  • Azathioprine
  • Children
  • Crohn's disease
  • Immunomodulator
  • Inflammatory bowel disease
  • Surgery

ASJC Scopus subject areas

  • Gastroenterology


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