Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Alexander M. Panich, Moti Salti, Aleksandr E. Aleksenskii, Yuri V. Kulvelis, Anastasia Chizhikova, Alexander Ya Vul', Alexander I. Shames

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.

Original languageEnglish
Article number109591
JournalDiamond and Related Materials
Volume131
DOIs
StatePublished - 1 Jan 2023

Keywords

  • Grafting
  • Magnetic resonance imaging (MRI)
  • Manganese
  • Nanodiamond
  • Nuclear magnetic resonance (NMR)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Mechanical Engineering
  • Materials Chemistry
  • Electrical and Electronic Engineering

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