TY - JOUR
T1 - Suspensions of manganese-grafted nanodiamonds
T2 - Preparation, NMR, and MRI study
AU - Panich, Alexander M.
AU - Salti, Moti
AU - Aleksenskii, Aleksandr E.
AU - Kulvelis, Yuri V.
AU - Chizhikova, Anastasia
AU - Vul', Alexander Ya
AU - Shames, Alexander I.
N1 - Funding Information:
We thank Eli Atiya and Philip Rosen for help in making MRI measurements and Engineering Department of the St. Petersburg Technological Institute (Technical University) for use of scanning electron microscope equipped with the EDX unit. Research by A.A., A.Ch., and A.V. was supported under the Ioffe Institute project 0040-2019-0013 .
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.
AB - We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.
KW - Grafting
KW - Magnetic resonance imaging (MRI)
KW - Manganese
KW - Nanodiamond
KW - Nuclear magnetic resonance (NMR)
UR - http://www.scopus.com/inward/record.url?scp=85145600247&partnerID=8YFLogxK
U2 - 10.1016/j.diamond.2022.109591
DO - 10.1016/j.diamond.2022.109591
M3 - Article
AN - SCOPUS:85145600247
SN - 0925-9635
VL - 131
JO - Diamond and Related Materials
JF - Diamond and Related Materials
M1 - 109591
ER -