Sustained virological response following an 11-day course of direct acting antiviral therapy for hepatitis c infection

David Yardeni, Vitaliy Dizengof, Anat Nevo-Shor, Naim Abu Freha, Harel Dahari, Ohad Etzion

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

The genetic risk factors of chronic pancreatitis (CP) include mutations in several genes, notably serine protease 1 (PRSS1), serine peptidase inhibitor (SPINK1), cystic fibrosis transmembrane conductance regulator (CFTR), cathepsin B (CTSB), chymotrypsin C (CTRC) and calcium sensing receptor (CASR). A genome wide association (GWAS) study in European populations revealed that polymorphisms in PRSS1and claudin 2 (CLDN2) - MORC family CW-type zinc finger 4 (MORC4) locus were associated with CP [1]. Replication studies carried out globally, including two studies from north and south India have validated many findings of the GWAS [2, 3]. No genetic data regarding CP were reported for the North-Eastern (NE) Indian population, as this population has a different genetic pattern than north or south India [4]. For the first time, we carried out a candidate gene association study in this population using previously validated markers significantly associated with CP in other populations.
Original languageEnglish
Pages (from-to)274-275
Number of pages2
JournalJournal of Gastrointestinal and Liver Diseases
Volume29
Issue number2
DOIs
StatePublished - 1 Jun 2020

ASJC Scopus subject areas

  • General Medicine

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